Picrorrhiza kurroa in Safini Syrup is having efficacy in liver and blood disorders. It is also effective in leucoderma. Tinospora cordifolia is a natural blood purifier and is very useful for skin problems like acne, psoriasis, eczema, lichen planus. It is well known immunomodulator. Fumaria officinalis is well known for its efficacy as a liver tonic, as a gallbladder tonic, as an emollient and as a diuretic. Swertia chirata has herbal applications as a bitter tonic, stomachic and as a febrifuge. Azadirachta indica is one of the best known bitter tonic that helps detoxification and improves immune system. It has anti-viral and anti-bacterial properties and work excellently in skin disorders and liver problems.